National Institute for Health Research
Kleijnen Systematic Reviews Ltd is a "Centre of Excellence" for Technology Assessment Reviews (TARs), appointed by the National Institute for Health Research (NIHR).
TARs provide a reliable and rigorous evidence assessment of the benefits, harms and costs of particular healthcare treatments for those who plan, provide or receive care in the NHS.
TARs are commissioned to meet the urgent needs of national NHS decision-making bodies and policy customers, such as the National Institute for Health and Care Excellence (NICE). TARs are most commonly produced to inform NICE Appraisal Committee guidance on the use of new and existing medicines, treatments and procedures within the NHS in England and Wales.
Current projects include:
New projects will appear on a regular basis.
Completed projects include:
- ImmunoCAP ISAC for multiplex allergen testing in patients with complex allergic disease
- The Elecsys Troponin T High-Sensitive test to aid the diagnosis and risk stratification of acute myocardial infarction in people with acute chest pain
- The ROTEM Delta point-of-care analyser to assist with the diagnosis, management and monitoring of haemostasis during and after surgery
- Naloxegol for treating opioid-induced constipation [ID674]
- Sensor-augmented pump therapy in diabetes using the MiniMed Paradigm Veo System
- BRAHMS PCT Sensitive Kryptor assay for the diagnosis and monitoring of sepsis
- Assessment to confirm an anaphylactic episode and the decision to refer after emergency treatment for a suspected anaphylactic episode
- Apixaban for the prevention of venous thromboembolism in people undergoing elective knee and hip replacement surgery
- Golimumab for Ankylosing Spondylitis (AS)
- Tocilizumab for the treatment of Systemic Juvenile Idiopathic Arthritis (JIA)
- Roflumilast for the Management of Chronic Obstructive Pulmonary Disease (COPD)
- Ivacaftor for Cystic Fibrosis G551D mutation
- Mannitol Dry Powder for Inhalation for the Treatment of Cystic Fibrosis (CF)
- Computed tomography (CT) scanners for cardiac imaging – Somatom Definition Flash, Aquilion One, Brilliance iCT and Discovery CT750 HD
- SonoVue® (sulphur hexafluoride microbubbles) - contrast agent for contrast enhanced ultrasound in liver imaging
- SeHCAT (Tauroselcholic [75 selenium] acid) for the investigation of bile acid malabsorption (BAM) and measurement of bile acid pool loss
- Rapid fetal fibronectin (fFN) testing to predict pre-term birth in women with symptoms of premature labour: A systematic review and cost effectiveness analysis
- Axitinib for the treatment of advanced renal cell carcinoma after failure of prior systematic treatment
- Lenalidomide for the treatment of myelodysplastic syndromes associated with deletion 5q cytogenetic abnormality (ID480)